Rimelike Structure-Inspired Approach toward in Situ-Oriented Self-Assembly of Hierarchical Porous MOF Films as a Sweat Biosensor.

Surface-supported metal-organic framework (MOF) films hold fantastic promises for viable scientific applications, particularly in sensors and electronic devices. However, slow diffusion, limited mass transfer, and low conductivity hinder the industrial application of MOFs. Herein, we propose a rime-inspired MOF film based on a kind of beautiful natural landscape. To mimic rime architecture, we compare and conclude the intrinsic similarity between natural biomineralization and electrochemical self-assembly of MOFs and used an anodic-induced approach to producing rime-structured MOF architecture. Interestingly, the MOF film with space-filling macro-meso-micropores exhibits remarkable electrochemical sensing performances for simultaneous determination of lactate and glucose, including high sensitivity, excellent selectivity, and a wide linear range in a wide range of pH values. Moreover, this rime-inspired system is able to be applied as a biofunctional human perspiration sensing platform. Our work opens a new horizon for poring on biomimetic rime concept to explore specifically structured MOFs with more diverse functionalities.