2018

A novel mass spectrometry method based on competitive non-covalent interaction for the detection of biomarkers.

Chemical communications (Cambridge, England) Han J, Li Y, Zhan L, Xue J, Sun J, Xiong C, Nie Z
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英文摘要

We report a novel biosensor platform based on competitive non-covalent interaction between ssDNA and a mass tag towards AuNPs, which detects PSA biomarkers sensitively, observed using MALDI MS. A detection limit of 57 pg mL-1 has been achieved, showing an improvement of two orders of magnitude compared to the traditional spectroscopic method.

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