Study on the limit of detection in MZI-based biosensor systems.

Mach-Zehnder interferometers are integrated photonic sensors that have yielded excellent detection limits down to 10-7 RIU. They are of particular interest due to their large design freedom, allowing for example application in promising point-of-care compatible read-out schemes. The attainable detection limit of such sensors can interact with the sensor design in different ways, depending on the dominant origin of noise which can either be influencing a single sensor arm, both sensor arms or can be unrelated to the sensor itself. In this work, the interaction of these three noise regimes with the sensor design is examined. The regimes are combined into a framework that predicts the limit of detection as a function of sensor design. A set of experimental results confirms the validity of this obtained theoretical framework. This analysis provides a blueprint for optimization of MZI photonic sensors under any combination of read-out method and measurement circumstances.