Universal and label-free photosensitization colorimetric assays enabled by target-induced termini transformation of dsDNA resistant to Exo III digestion.

A label-free and universal photosensitization colorimetric assay based on target-induced dsDNA termini switching has been developed for the analysis of nucleic acids, proteins, small molecules and metal ions. This strategy is highly sensitive and versatile, the principle of which will be desirable for various biosensor developments and applications.