Single-Walled Carbon Nanotubes (SWCNTs) and Poly(3,4-ethylenedioxythiophene) Nanocomposite Microwire-Based Electronic Biosensor Fabricated by Microlithography and Layer-by-Layer Nanoassembly.

Cost-effective single-walled carbon nanotubes (SWCNTs) and poly(3,4-ethylenedioxythiophene) nanocomposite-microwire (N-MWs) electronic biosensor was fabricated by microlithography and layer-by-layer nanoassembly. Using N-MWs, we not only can achieve accurate large-scale registration and integration of nanoscale materials into a functional device, but also can enhance the sensing surface area significantly, which can open great opportunities for the cost-effectively fabrication of ultrasensitive biosensors. Using the binding assay between Protein A and Rabbit Immunoglobulin G (IgG) as a model, measurements find that the N-MWs electronic biosensor, containing carbon nanotubes (CNTs) and conductive polymers, exhibits field effect and the resistance changes upon its binding to biomolecules. The effect of the dimensions of the N-MWs on the sensitivity of the sensor has also been evaluated.