10.1021/acssensors.9b01713

In vivo electrochemical sensing based on implantable microelectrodes is a strong driving force of analytical neurochemistry in brain. The complex and dynamic neurochemical network sets stringent standards of in vivo electrochemical sensors including high spatiotemporal resolution, selectivity, sensitivity, and minimized disturbance on brain function. Although advanced materials and novel technologies have promoted the development of in vivo electrochemical sensors drastically, gaps with the goals still exist. This Review mainly focuses on recent attempts on the key issues of in vivo electrochemical sensors including selectivity, tissue response and sensing reliability, and compatibility with electrophysiological techniques. In vivo electrochemical methods with bare carbon fiber electrodes, of which the selectivity is achieved either with electrochemical techniques such as fast-scan cyclic voltammetry and differential pulse voltammetry or based on the physiological nature will not be reviewed. Following the elaboration of each issue involved in in vivo electrochemical sensors, possible solutions supported by the latest methodological progress will be discussed, aiming to provide inspiring and practical instructions for future research.