Cellular electrode for antitumor drug screening.

Mouse leukemia L1210, a well established tumor model, can be immobilized near the surface of a dissolved O(2) probe and its O(2) uptake can be monitored continuously following the addition of various chemicals such as Mechlorethamine HCl, an antitumor agent. The output current of the O(2) electrode changed as a function of time under various experimental conditions. The dynamic response of the electrochemical sensor was determined as a function of antitumor agent concentration. A preliminary kinetic model was developed to describe the biosensor behavior.