A comparative electrochemical study of non-enzymatic glucose, ascorbic acid, and albumin detection by using a ternary mesoporous metal oxide (ZrO

In this study, we present an electrochemical investigation of a ternary mesoporous metal oxide (ZrO2, SiO2 and In2O3) modified graphene composite for non-enzymatic glucose, ascorbic acid, and albumin detection in urine at physiological pH. Synergetic property of ZrO2-Ag-G-SiO2 and In2O3-G-SiO2 were investigated via cyclic voltammetry (CV) using FTO glass and copper-foil electrodes with no prerequisite of solid antacid expansion. The mesoporous ZrO2-Ag-G-SiO2 and In2O3-G-SiO2 composites were synthesized and characterized using XRD, SEM, TEM, Raman spectroscopy, XPS, DRS, BET, and photocurrent measurements. Upon increasing the glucose concentration from 0 to 3 mM, CV results indicated two anodic peaks at +0.18 V and +0.42 V versus Ag/AgCl, corresponding to Zr3+ and Zr4+, respectively, considering the presence of glucose in urine. Moreover, the effects of high surface area In2O3-G-SiO2 were observed upon the examination of ZrO2-Ag-G-SiO2. In2O3-G-SiO2 demonstrated a decent electrochemical pattern in glucose, ascorbic acid, and albumin sensing. Nevertheless, insignificant synergistic effects were observed in In2O3-G, ZrO2-G, and ZrO2-G-SiO2. In2O3-G-SiO2 performed well under a wide range of electrolytes and urine, and showed no activity toward uric acid, suggesting potential for biodetection in urine.