Spatially-extended 3D magnetic DNA nanodevice-based split-type photoelectrochemical strategy for sensitive and reliable miRNA detection in cancer cells.

Highly sensitive and reliable PEC detection of miRNAs still faces some challenges like the inaccuracy caused by coexisting interferences in the PEC system. Herein, we developed a split-type "turn-off" PEC biosensor based on spatially-extended 3D magnetic DNA nanodevices with high-order DNA amplifiers for sensitive detection of miRNAs in cancer cells.