Target protein induced cleavage of a specific peptide for prostate-specific antigen detection with positively charged gold nanoparticles as signal enhancer.

In this work, a new "signal-on" electrochemical biosensor for sensitive detection of prostate-specific antigen (PSA) was developed on the basis of target protein induced cleavage of a specific peptide with positively charged gold nanoparticles (AuNPs) as signal enhancer.