共 39 条结果,关键词「CRISPR」
Research (Washington, D.C.)
2024
Wang J, Duan Z, Luo D
In the post-COVID-19 pandemic era, the long-term surveillance of pathogens is still important. The rapid detection of pathogens facilitates the accurate and convenient...
Journal of nanobiotechnology
2024
Yao S, Liu Y, Ding Y, Shi X 等 7 人
The detection of carcinoembryonic antigen (CEA) holds significant importance in the early diagnosis of cancer. However, current methods are hindered by limited accessi...
Biosensors
2024
Li X, Wang H, Qi X, Ji Y 等 8 人
RNA is an important information and functional molecule. It can respond to the regulation of life processes and is also a key molecule in gene expression and regulatio...
ACS sensors
2024
Freko S, Nikić M, Mayer D, Weiß LJK 等 6 人
The rapid and reliable detection and quantification of nucleic acids is crucial for various applications, including infectious disease and cancer diagnostics. While co...
Proceedings of the National Academy of Sciences of the United States of America
2024
Liao Y, Muntean BS
Dopamine transfers information to striatal neurons, and disrupted neurotransmission leads to motor deficits observed in movement disorders. Striatal dopamine converges...
Nature communications
2024
De Carluccio G, Fusco V, di Bernardo D
Inducible gene expression systems can be used to control the expression of a gene of interest by means of a small-molecule. One of the most common designs involves eng...
Frontiers in plant science
2024
Kanapiya A, Amanbayeva U, Tulegenova Z, Abash A 等 7 人
Accurate and timely diagnosis of plant viral infections plays a key role in effective disease control and maintaining agricultural productivity. Recent advances in the...
ACS omega
2024
Ertuğrul Uygun HD, Odaci D
This study introduces a novel biosensing approach for the detection of pathogen DNA in breast milk utilizing single carbon fiber electrodes (SCFE) enhanced with MXene ...
Nature communications
2024
Deng F, Li Y, Yang B, Sang R 等 10 人
Control of CRISPR/Cas12a trans-cleavage is crucial for biosensor development. Here, we show that small circular DNA nanostructures which partially match guide RNA sequ...
Sensors (Basel, Switzerland)
2024
Hasan MR, Mughees M, Shaikh S, Choudhary F 等 11 人
Breast cancer stands as the most prevalent form of cancer amongst females, constituting more than one-third of all cancer cases affecting women. It causes aberrant cel...
Advanced science (Weinheim, Baden-Wurttemberg, Germany)
2024
Zhang Q, Hao Y, Zeng T, Shu W 等 13 人
Graphene field-effect transistors (GFETs) are widely used in biosensing due to their excellent properties in biomolecular signal amplification, exhibiting great potent...
Communications biology
2024
Brenner LM, Meyer F, Yang H, Köhler AR 等 9 人
Through its involvement in gene transcription and heterochromatin formation, DNA methylation regulates how cells interact with their environment. Nevertheless, the ext...
Exploration (Beijing, China)
2024
Zhang Y, Chen Z, Wei S, Zhang Y 等 8 人
Real-time polymerase chain reaction (RT-PCR) remains the most prevalent molecular detection technology for sewage analysis but is plagued with numerous disadvantages, ...
Breast cancer research : BCR
2024
Liao CC, Long Y, Tsai ML, Lin CY 等 6 人
Autophagy, a crucial process in cancer, is closely intertwined with both tumor progression and drug resistance development. However, existing methods used to assess au...
Frontiers in bioengineering and biotechnology
2024
Huang H, Li S, Han X, Zhang Y 等 8 人
Osteoarthritis (OA) has become a serious problem to the human society for years due to its high economic burden, disability, pain, and severe impact on the patient's l...
Frontiers in cellular and infection microbiology
2024
Ma C, Zou M, Xu N, Liu Y 等 5 人
Cervical cancer is the third most common cancer threatening women's health globally, and high-risk human papillomavirus (HR-HPV) infection is the main cause of cervica...
Biomedicines
2024
Yarkova ES, Grigor'eva EV, Medvedev SP, Tarasevich DA 等 9 人
Endoplasmic reticulum (ER) stress is involved in the pathogenesis of many human diseases, such as cancer, type 2 diabetes, kidney disease, atherosclerosis and neurodeg...
Synthetic and systems biotechnology
2024
Peng Q, Bao W, Geng B, Yang S
Lactate is an important monomer for the synthesis of poly-lactate (PLA), which is a substitute for the petrochemical plastics. To achieve the goal of high lactate tite...
Autophagy reports
2024
Tang J, Yoon N, Dadson K, Sung HK 等 16 人
Myocardial ischemia/reperfusion (I/R) injury is exacerbated in diabetic individuals and animal models. We tested whether autophagy is an important cellular determinant...