25874 条结果

Neo-Cysteine Molecular Glues for Targeting Mutated SMAD4 Protein.

Angewandte Chemie (International ed. in English) 2026 Kumari P, Oum YH, Miller EJ, Qui M 等 9 人

Neo-protein-protein interactions (neoPPIs), directed by genetic mutation-encoded neo-amino acid residues, represent a promising class of precision medicine targets. Sm...

Pathogenic Gαo Mutants Drive Dominant GPCR Coupling in GNAO1 Encephalopathies.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2026 Larasati YA, de Meritens CR, Stoeber M, Katanaev VL 等 5 人

Heterozygous mutations in GNAO1, which encodes the Gαo subunit of heterotrimeric G proteins, cause a spectrum of neurodevelopmental disorders ranging from early-onset ...

Mussel-Bioinspired Edible Ca

Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2026 Marchianò V, Pellegrini C, Tricase A, Macchia E 等 11 人

A novel self-standing, edible polydopamine-based alginate-hydrogel electrode that intrinsically conducts ions and electrons is introduced, redefining the architecture ...