Glutamate dehydrogenases in fungi: From biology to biotechnology.
Glutamate dehydrogenases (GDH; EC 1.4.1.2 and EC 1.4.1.4) play a pivotal role in fungal nitrogen metabolism by catalyzing the reversible conversion of 2-ketoglutarate ...
Detection of paralytic shellfish toxins and tetrodotoxins in shellfish using a single-cell biosensor based on patch clamp technology.
Paralytic shellfish toxins (PSTs) are a well-known group of potent neurotoxins that may accumulate in shellfish, posing a significant risk to food safety and public he...
Algorithm-assisted interpretation of cyclic and differential pulse voltammetry for cardiac troponin detection.
Cardiovascular disease remains a leading cause of mortality worldwide, and rapid identification of cardiac biomarkers is essential for early detection. Electrochemical...
Correction: colorimetric and electrochemical assessment of starch based highly sensitive origami glucose biosensor over fabric: A potentially sensitive substitute of chitosan.
A Spore-Based Biosensor-on-Pillar Platform for Detecting ß-Lactam Antibiotics in Milk.
Antimicrobial resistance (AMR) is increasingly becoming a major global public health concern, as antibiotics are losing their effectiveness at an alarming rate due to ...
PdMo Bimetallene as a High-Performance Electrochemical Sensor for the Selective Detection of Dopamine.
Dopamine (DA) is a crucial catecholamine neurotransmitter, and its abnormal levels are closely associated with neurological disorders such as Parkinson's disease. Elec...
Headset-Type Biofluorometric Gas Sensor with CMOS for Transcutaneous Ethanol from the Ear Canal.
This study presents a headset-type biofluorometric gas sensor incorporating a CMOS camera for continuous, non-invasive monitoring of transcutaneous ethanol from the ea...
Computational Simulation of a Surface Plasmonic Resonance Biosensor for β2-Microglobulin Based on Electrolyte-Gated Graphene.
Biosensors have emerged as a rapidly evolving area of research, offering transformative potential across biomedical diagnostics, environmental monitoring, and pharmace...
Molecular profiling of alpha-synuclein pathology and seeding activity in Parkinson's disease.
Parkinson's disease (PD) is neuropathologically characterized by the abnormal accumulation of fibrillar alpha-synuclein (aSyn) within selectively vulnerable neuronal p...
Protein-free colorimetric biosensor for sensitive detection of HPV-18 mRNA via MNAzyme-driven catalytic hairpin assembly.
Cervical cancer is significantly associated with persistent infection of human papillomavirus (HPV) type 18, making accurate detection of low-abundance HPV-18 mRNA cru...
Racetrack ring resonator-assisted MZI-based integrated optical biosensor with buffer layers for measuring blood glucose level.
In this study, we present a two-racetrack ring assisted Mach-Zehnder interferometer (RRAMZI) configuration, specifically engineered for glucose detection. RRAMZI chose...
Development of a quality control test for diphtheria vaccine based on an electrochemical aptamer-based biosensor.
At every stage of the vaccine's development, including research and development together with the routine production (in-process control of batch release), quality con...
ITO-PET electrochemical biosensor functionalized with carboxylated graphene oxide for prostate cancer biomarker detection.
Prostate cancer is considered the third most diagnosed malignancy worldwide, and early diagnosis is crucial for effective treatment and improved patient outcomes. In c...
Comparing UV-enhanced and direct reduction strategies for CD8⁺ T-cell electrochemical detection.
A novel electrochemical biosensor was developed for accurate and sensitive detection of CD8+ T cells, as a key biomarker in clinical and immunological analysis. A scre...
De novo and scaffold-based design of GDF15 binders for cancer cachexia diagnostics and therapeutics.
Growth differentiation factor-15 (GDF15), a stress-responsive cytokine of the transforming growth factor-β superfamily, is elevated in cancer cachexia, chemotherapy-in...
Metal Modulation of Oxytocin Structure, Function, and Receptor Interactions.
Oxytocin is a nine-amino acid peptide hormone essential for reproduction, social bonding, and neuromodulation. Accumulating evidence demonstrates that divalent metal i...
GPR3 Ligands Discovered through Combined Virtual and Conformational Biosensor-Based Screening.
GPR3 belongs to the protein superfamily of G protein-coupled receptors (GPCRs) and plays a central role in both benign and malignant physiological processes, such as e...
Rapid, point-of-care, visual detection of RBD of SARS-CoV-2 spike protein using an acrylamide-free photonic crystal aptasensor.
As COVID-19 continues to reemerge with new variants, it has become a persistent challenge to public health, causing disruptions in society and the economy. We report a...
Illuminating compartmentalized AMPK signaling in single cells.
AMP-activated protein kinase (AMPK) is a crucial regulator of cellular energy balance, affecting numerous downstream targets across various subcellular locations. Unde...
Breaking the catalysis-quenching dilemma in covalent organic frameworks with metal single-atom sites for enhanced electrochemiluminescence.
Precise incorporation of metal single-atom (SA) active sites into covalent organic frameworks (COFs) offers a powerful approach to enhance electrochemiluminescence (EC...