共 8 条结果,关键词「CRISPR」
Angewandte Chemie (International ed. in English)
2019
Dai Y, Somoza RA, Wang L, Welter JF 等 7 人
An accurate, rapid, and cost-effective biosensor for the quantification of disease biomarkers is vital for the development of early-diagnostic point-of-care systems. T...
Nature biomedical engineering
2019
Hajian R, Balderston S, Tran T, deBoer T 等 16 人
Most methods for the detection of nucleic acids require many reagents and expensive and bulky instrumentation. Here, we report the development and testing of a graphen...
Molecular ecology resources
2019
Williams MA, O'Grady J, Ball B, Carlsson J 等 9 人
We report the first application of CRISPR-Cas technology to single species detection from environmental DNA (eDNA). Organisms shed and excrete DNA into their environme...
Metabolic engineering communications
2019
Advanced materials (Deerfield Beach, Fla.)
2019
Bruch R, Baaske J, Chatelle C, Meirich M 等 8 人
Noncoding small RNAs, such as microRNAs, are becoming the biomarkers of choice for multiple diseases in clinical diagnostics. A dysregulation of these microRNAs can be...
Methods in molecular biology (Clifton, N.J.)
2019
Bourque K, Devost D, Inoue A, Hébert TE
Ligand-biased signaling could have a significant impact on drug discovery programs. As such, many approaches to screening now target a larger section of the signaling ...
JCI insight
2019
Lynch MR, Tran MT, Ralto KM, Zsengeller ZK 等 16 人
Because injured mitochondria can accelerate cell death through the elaboration of oxidative free radicals and other mediators, it is striking that proliferator gamma c...
Methods in enzymology
2019
Wayment-Steele H, Wu M, Gotrik M, Das R
Riboswitches are RNA elements that recognize diverse chemical and biomolecular inputs, and transduce this recognition process to genetic, fluorescent, and other engine...