The effect of sub-inhibitory concentrations of rifaximin on urease production and on other virulence factors expressed by Klebsiella pneumoniae, Proteus mirabilis, Pseudomonas aeruginosa and Staphylococcus aureus.

利福昔明是利福平衍生的局部作用抗生素，口服后吸收差，可在肠道达到远高于最低抑菌浓度（MIC）的水平。本研究评估亚MIC利福昔明对参与肝性脑病的肺炎克雷伯菌、奇异变形杆菌、铜绿假单胞菌及金黄色葡萄球菌毒力因子的影响。结果显示，利福昔明在亚MIC浓度下抑制脲酶产生：所有奇异变形杆菌和肺炎克雷伯菌菌株以及全部受试铜绿假单胞菌分离株的脲酶表...