2 条结果 关键词:免疫检查点抑制剂 ×

A novel biomimetic nanoplasmonic sensor for rapid and accurate evaluation of checkpoint inhibitor immunotherapy.

Analytical and bioanalytical chemistry 2024 Batool R, Soler M, Singh R, Lechuga LM

免疫检查点抑制剂(ICIs)通过激活患者免疫系统清除肿瘤细胞,已成为癌症免疫治疗的重要策略,但肿瘤异质性、耐药机制及复杂体外检测限制了其广泛应用。为此,作者提出一种仿生无标记纳米等离子体生物传感器,用于快速、可靠地筛选和评估检查点抑制剂。该传感器基于低密度金纳米盘阵列,可直接在其表面形成功能化支撑脂质双分子层(SLB),作为人工细胞...

Novel ultrasensitive automated kinetic exclusion assay for measurement of plasma levels of soluble PD-L1, the predictive and prognostic biomarker in cancer patients treated with immune checkpoint inhibitors.

Heliyon 2024 Darwish IA, Alahmad W, Vinoth R

血浆或血清中可溶性程序性死亡配体1(PD-L1)水平被提出作为免疫检查点抑制剂治疗癌症患者的预测和预后生物标志物,但现有方法灵敏度、重现性和准确性有限。本研究开发超灵敏自动化流动式动力学排除分析(KinExA),用于血浆可溶性PD-L1的准确测量。基于KinExA™ 3200生物传感器,样品中PD-L1先与抗PD-L1单克隆抗体预平...