Distinguishment of populated metastatic cancer cells from primary ones based on their invasion to endothelial barrier by biosensor arrays fabricated on nanoroughened poly(methyl methacrylate).
确定癌细胞的迁移与侵袭能力,并阐明其机制,对癌症诊断、预后、药物开发和治疗具有重要意义。转移细胞侵入血管层是转移的关键特征,已有多种生化与生物电传感器用于转移早期检测,但装置复杂、读出困难、难以检测稀有转移细胞且依赖特殊设备,限制了临床应用。本文报道一种基于 Metas-Chip 的电化学阻抗生物传感器,利用反应离子刻蚀制备的纳米粗...