Fe₃O₄@Ag magnetic nanoparticles for microRNA capture and duplex-specific nuclease signal amplification based SERS detection in cancer cells.

本文报道了一种用于捕获和超灵敏检测癌细胞总RNA提取液中microRNA（miRNA）的功能化Fe3O4@Ag磁性纳米颗粒（NP）生物传感器。该传感器将拉曼标签-DNA探针修饰的Fe3O4@Ag NPs同时作为表面增强拉曼散射（SERS）平台和双链特异性核酸酶信号放大（DSNSA）平台。首先，目标miRNA通过DNA/RNA杂交被捕...