Development of a bioaffinity SPR immunosensor based on functionalized graphene oxide for the detection of pregnancy-associated plasma protein A2 in human plasma.

本文报道了一种基于羧基化氧化石墨烯（carboxyl-GO）的表面等离子共振（SPR）免疫传感器，用于人血浆中妊娠相关血浆蛋白A2（PAPPA2）的检测。研究提出通过共价固定与封闭策略降低人血浆中非特异性蛋白干扰。carboxyl-GO可调节等离激元共振能量、功函数和导电性，其羧基可增强与金电极间的电子传导；复合介质电场放大效应使表...