An ultrasensitive biosensor for prostate specific antigen detection in complex serum based on functional signal amplifier and designed peptides with both antifouling and recognizing capabilities.

在复杂生物介质中避免生物污损并灵敏检测生物标志物仍是生物传感器领域的挑战。本文设计了一种基于特异性抗污损肽和信号放大策略的超低污损、高灵敏电化学生物传感器，用于人血清中前列腺特异性抗原（PSA）检测。首先，在玻璃碳电极表面电沉积聚乙二醇（PEG）掺杂聚(3,4-乙烯二氧噻吩)（PEDOT）形成低污损导电多孔层；随后固定链霉亲和素（S...