Comparative study of immunoassays, a microelectromechanical systems-based biosensor, and RT-QuIC for the diagnosis of chronic wasting disease in white-tailed deer.

慢性消耗性疾病（CWD）是鹿科动物致死性传染性海绵状脑病，由致病朊病毒PrPSc引起。目前诊断依赖免疫组化（IHC）检测脑干终板或咽后淋巴结（RPLN）中PrPSc，或ELISA筛查后IHC确认。本研究评估CWD Ag-ELISA、TeSeE ELISA、RT-QuIC和MEMS生物传感器对30份CWD+及30份CWD-白尾鹿RPL...