A novel viral strategy for host factor recruitment: The co-opted proteasomal Rpn11 protein interaction hub in cooperation with subverted actin filaments are targeted to deliver cytosolic host factors for viral replication.

正链RNA病毒通过劫持大量宿主蛋白因子、运输囊泡和细胞器构建膜性病毒复制器官（VRO），以支持高效RNA复制。番茄丛矮病毒（TBSV）中，单一复制蛋白p33承担大部分宿主因子招募任务，但其如何快速、高效招募大量胞质宿主蛋白仍不清楚。本文表明，TBSV p33并非逐一招募每个胞质宿主因子，而是靶向胞质蛋白互作枢纽Rpn11。Rpn11...