4 条结果 关键词:癌症标志物 ×

An enzyme-free electrochemical biosensor based on target-catalytic hairpin assembly and Pd@UiO-66 for the ultrasensitive detection of microRNA-21.

Analytica chimica acta 2020 Meng T, Shang N, Nsabimana A, Ye H 等 7 人

microRNA-21(miR-21)是癌症诊断与治疗中重要的生物标志物。本文提出一种基于钯负载金属有机框架(Pd@UiO-66)和目标催化发夹组装(CHA)的高灵敏非酶电化学生物传感器,用于检测 miR-21。该传感器将高效的 CHA 信号放大策略与 Pd@UiO-66 纳米复合物的优异电催化性能相结合,采用目标循环机制:miR-...

A chemiresistive biosensor based on a layered graphene oxide/graphene composite for the sensitive and selective detection of circulating miRNA-21.

Biosensors & bioelectronics 2020 Huang CH, Huang TT, Chiang CH, Huang WT 等 5 人

本研究开发了一种均匀、大面积的氧化石墨烯/石墨烯(GO/G)层状复合结构,用于检测循环 miRNA-21,该分子是早期癌症诊断的可靠生物标志物。作者通过低损伤等离子体处理(LDPT)对双层石墨烯(BiG)进行原子层氧化,使顶层石墨烯被氧化为 GO 层,作为生物识别受体;底层石墨烯保持导电性,作为电响应介质。基于该结构,构建了简单的化...

Ultrasensitive Fluorescent miRNA Biosensor Based on a "Sandwich" Oligonucleotide Hybridization and Fluorescence Resonance Energy Transfer Process Using an Ln(III)-MOF and Ag Nanoparticles for Early Cancer Diagnosis: Application of Central Composite Design.

ACS applied materials & interfaces 2020 Afzalinia A, Mirzaee M

本文报道了一种基于寡核苷酸“三明治”杂交和荧光共振能量转移(FRET)策略的新型荧光生物传感器,用于快速、高灵敏、高选择性地检测癌症生物标志物miRNA-155的表达水平。该传感器以改性La(III)金属有机框架(La(III)-MOF)和银纳米颗粒(Ag NPs)作为FRET供体–受体对,通过荧光猝灭实现信号转换。La(III)-...

Highly sensitive IRS based biosensor for the determination of cytochrome c as a cancer marker by using nanoporous anodic alumina modified with trypsin.

Biosensors & bioelectronics 2020 Amouzadeh Tabrizi M, Ferré-Borrull J, Marsal LF

检测人血清中细胞色素c(Cyt C)是评估癌症的常规医学检测。本文构建了基于干涉反射光谱(IRS)的生物传感器用于检测 Cyt C。首先制备纳米孔阳极氧化铝(NAA),随后用3-氨基丙基三甲氧基硅烷对 NAA 孔壁进行功能化得到 NAA-NH2,再将胰蛋白酶(Tryp)固定于 NAA 孔壁。该 IRS 传感器检测 Cyt C 的原理...