Highly selective detection of bacterial alarmone ppGpp with an off-on fluorescent probe of copper-mediated silver nanoclusters.

细菌警报素ppGpp（guanosine 3′-diphosphate-5′-di(tri)phosphate）在细菌遭遇营养缺乏等应激时迅速生成，并参与 stringent response（严格反应）、基因表达、抗生素产生和毒力等过程。传统HPLC方法灵敏度有限，而有机荧光配体合成复杂且难以区分ppGpp与其他磷酸盐。本文基于C...