Sensitive and selective detection of biothiols based on target-induced agglomeration of silver nanoclusters.
本文提出一种无标记生物传感器,用于检测半胱氨酸(Cys)、同型半胱氨酸(Hcy)和谷胱甘肽(GSH)等生物硫醇。该传感器基于聚乙烯亚胺包覆的荧光银纳米团簇(PEI-capped AgNCs)探针。生物硫醇与银纳米团簇选择性结合,促进银纳米团簇聚集形成更大的非荧光银纳米颗粒,使探针荧光强度随生物硫醇浓度增加而有效猝灭。其他不含巯基的氨...