Determination of binding capacity and adsorption enthalpy between Human Glutamate Receptor (GluR1) peptide fragments and kynurenic acid by surface plasmon resonance experiments.

本研究利用表面等离子共振（SPR）光谱学，考察犬尿喹啉酸（KYNA）与人谷氨酸受体1（GluR1）201–300区两个约30个残基肽片段（GluR1201–230和GluR1231–259）的相互作用。GluR1是α-氨基-3-羟基-5-甲基-4-异噁唑丙酸（AMPA）受体的重要亚基，AMPA受体介导快速突触传递并参与脑可塑性；KY...