Activation of endothelial transient receptor potential C3 channel is required for small conductance calcium-activated potassium channel activation and sustained endothelial hyperpolarization and vasodilation of cerebral artery.

瞬时受体电位C3（TRPC3）已被证明通过内皮细胞（EC）超极化和内皮依赖性超极化介导的血管舒张参与血管张力调节，但其机制尚不清楚。本研究检验了内皮受体刺激可触发TRPC3快速转运至质膜，并为小电导钙激活钾通道（SKCa）激活和持续EC超极化提供Ca2+内流来源的假说。采用离体小鼠后脑动脉加压动脉实验，选择性TRPC3抑制剂Pyr3...