Photo-gated and self-powered three-dimensional DNA motors with boosted biostability for exceptionally precise and efficient tracing of intracellular survivin mRNA.

基于DNA马达（尤其是DNA walker）的生物传感概念因信号放大能力强、构建灵活，已成为细胞内检测的有力荧光成像工具。然而，现有方法可控性差、易产生假信号，且因常用DNAzyme而需外源供能。为此，本文提出光控与自供能策略：在金纳米颗粒（AuNP）表面引入光裂解模式，使DNA walker具有光控行走行为，可经外部紫外光选择性激...