2 条结果 关键词:酶活性 ×

TDP1 and TOP1 as targets in anticancer treatment of NSCLC: Activity and protein level in normal and tumor tissue from 150 NSCLC patients correlated to clinical data.

Lung cancer (Amsterdam, Netherlands) 2022 Jakobsen AK, Yuusufi S, Madsen LB, Meldgaard P 等 6 人

拓扑异构酶1(TOP1)是抗癌治疗靶点,但酪氨酸-DNA磷酸二酯酶1(TDP1)可修复TOP1药物诱导的DNA损伤,削弱其疗效。为阐明非小细胞肺癌(NSCLC)中联合靶向TDP1和TOP1的相关性,本研究首次对150例NSCLC患者的配对正常肺组织和肿瘤组织进行大样本定量,检测TDP1与TOP1酶活性及蛋白浓度,并关联临床数据。采用...

Field evaluation of quantitative point of care diagnostics to measure glucose-6-phosphate dehydrogenase activity.

PloS one 2018 Alam MS, Kibria MG, Jahan N, Thriemer K 等 10 人

葡萄糖-6-磷酸脱氢酶(G6PD)缺乏是全球最常见的酶病,但缺乏可靠的床旁定量检测。本研究在孟加拉国招募已知G6PD状态的参与者,评估两种新型定量G6PD即时诊断:Biosensor(BS,AccessBio/CareStart)和STANDARD G6PD(SG,SDBiosensor),并以分光光度法为参考。共入组158人,15...