A Turn Off Fluorescence Probe Based on Carbon Dots for Highly Sensitive Detection of BRCA1 Gene in Real Samples and Cellular Imaging.
本研究以Ferulago angulata热解制备水溶性碳点(CDs),构建用于乳腺癌相关基因BRCA1检测的“关型”荧光生物传感器。CDs表面羧基经EDC/NHS活化后,与19-mer氨基修饰寡核苷酸捕获探针共价偶联。加入BRCA1靶DNA后,捕获探针与靶序列特异性杂交,引起碳点荧光猝灭,从而通过荧光强度下降实现无标记、均相检测。...