Acceleration of DNA Hybridization Chain Reactions on 3D Nanointerfaces of Magnetic Particles and Their Direct Application in the Enzyme-Free Amplified Detection of microRNA.

利用DNA折纸作为支架加速DNA杂交链反应（HCR）在动态DNA纳米技术中备受关注，但DNA折纸支架需要定制设计，限制实际应用。本文以磁性微球（MBs）为简单三维支架，构建半局域HCR和局域HCR系统，用于无酶检测miR-21。半局域系统由游离发夹DNA-2（H2）和固定有发夹DNA-1（H1b-FQ）的MBs组成；局域系统由共固定...