Anti-CD155 and anti-CD112 monoclonal antibodies conjugated to a fluorescent mesoporous silica nanosensor encapsulating rhodamine 6G and fluorescein for sensitive detection of liver cancer cells.

本文开发了一种用于灵敏检测肝癌细胞的新方法：将抗CD155和抗CD112单克隆抗体偶联到包埋罗丹明6G和荧光素的超亮荧光介孔硅纳米颗粒（FMSN）上。所得纳米颗粒直径为90 nm，量子产率为69%。由于荧光素的发射光谱与罗丹明6G的激发光谱高度重叠，且两种染料在纳米颗粒上距离足够接近，二者之间可发生荧光共振能量转移。该能量转移不仅保...