Variable CGRP family peptide signaling durations and the structural determinants thereof.

αCGRP、βCGRP、AM和AM2/IMD通过激活与RAMP1-3偶联的CLR或CTR两类B类GPCR，参与疼痛、神经免疫及心血管/淋巴调节。本研究用活细胞BRET cAMP生物传感器CAMYEL比较两种CGRP肽及多种N端延伸不同的AM/AM2/IMD片段信号动力学。结果显示，AM2/IMD(8-47)和AM2/IMD-53在C...