A novel immuno-device based on the specific binding of AuNP-supported CTAB with biotinylated antibody of hyaluronic acid toward an early-stage recognition of a biomarker: a bioanalytical assay in real samples using disposal biosensor technology.
透明质酸(HA)是一种非硫酸化糖胺聚糖,可作为某些癌症诊断的潜在生物标志物。本文首次开发了一种基于改性ITO-PET电极的无标记电化学免疫传感器,用于实际样品中HA的灵敏识别。一次性ITO-PET电极经金纳米颗粒(AuNPs)修饰,构建适合固定化HA生物素化抗体的导电基底。该生物装置的创新点在于将HA生物素化抗体包埋于KCC1-NH...