Detection of Kallikrein-Related Peptidase 4 with a Label-free Electrochemical Impedance Biosensor Based on a Zinc(II) Phthalocyanine Tetracarboxylic Acid-Functionalized Disposable Indium Tin Oxide Electrode.

本研究首次报道了一种用于检测前列腺癌候选标志物Kallikrein-Related Peptidase 4（KLK4）的无标记电化学阻抗生物传感器。该传感器以氧化铟锡/聚对苯二甲酸乙二醇酯（ITO-PET）为工作电极，在其表面旋涂锌(II)酞菁四羧酸（Zn-PcTCa）作为界面基质。Zn-PcTCa端基羧基经EDC/NHS活化后，与...