Ratiometric Fluorescence Detection of Colorectal Cancer-Associated Exosomal miR-92a-3p with DSN-Assisted Signal Amplification by a MWCNTs@Au NCs Nanoplatform.
miRNA检测在疾病诊断中前景广阔。本文构建基于多壁碳纳米管@金纳米簇(MWCNTs@Au NCs)和双链特异性核酸酶(DSN)辅助信号放大的比率荧光生物传感器,用于检测结直肠癌相关外泌体miR-92a-3p。MWCNTs@Au NCs兼具荧光猝灭剂和内参荧光参考双重功能。无目标时,Atto-425标记单链DNA探针吸附于MWCNT...