Sandwich-type biosensor for the detection of α2,3-sialylated glycans based on fullerene-palladium-platinum alloy and 4-mercaptophenylboronic acid nanoparticle hybrids coupled with Au-methylene blue-MAL signal amplification.
α2,3-唾液酸化糖链(α2,3-sial-Gs)是癌症早期诊断的重要肿瘤标志物。本研究开发了一种新型三明治型电化学生物传感器,利用4-巯基苯硼酸(4-MPBA)构建分子识别体系,通过其硼原子与α2,3-sial-Gs中Neu5Ac酰胺基配位形成B-O键实现捕获。氨基功能化富勒烯负载钯铂双金属合金纳米晶(n-C60-PdPt)修饰玻...