A highly sensitive electrochemical biosensor for protein based on a tetrahedral DNA probe, N- and P-co-doped graphene, and rolling circle amplification.

四面体DNA探针可有效克服单链探针的空间位阻效应，实现探针密度可控并降低非特异性吸附。本文构建了一种用于蛋白质检测的高灵敏度电化学生物传感器，该传感器基于四面体DNA探针（T-DNA）和滚动环扩增（RCA）策略。首先制备氮、磷共掺杂石墨烯（NP-rGO），并在其表面电沉积金纳米颗粒（AuNPs）用于固定DNA探针。得益于NP-rGO...