Interference-free and high precision biosensor based on surface enhanced Raman spectroscopy integrated with surface molecularly imprinted polymer technology for tumor biomarker detection in human blood.
循环血液中肿瘤标志物的可靠定量分析对癌症早筛、治疗监测和预后预测至关重要。本文报道了一种结合表面增强拉曼光谱(SERS)与表面分子印迹聚合物(SMIP)技术的新型生物传感器,用于定量检测与多种常见癌症相关的癌胚抗原(CEA)。SMIP 可在 SERS 基底表面形成高亲和、稳定的特异识别位点,提高捕获能力。该传感器集成两层核壳纳米粒子...