Vaccine-induced antibodies to herpes simplex virus glycoprotein D epitopes involved in virus entry and cell-to-cell spread correlate with protection against genital disease in guinea pigs.

单纯疱疹病毒2型（HSV-2）糖蛋白D（gD2）亚单位抗原被纳入多种临床前候选疫苗，其目的是诱导抗体阻断介导病毒进入和细胞间扩散的关键gD2表位。在Herpevac女性试验中，gD2是唯一保护HSV-1生殖器感染而非HSV-2的抗原，且gD2 ELISA滴度与HSV-1保护相关。本研究评估免疫豚鼠中中和抗体及针对7个关键线性/构象g...