Graphene Oxide Biosensors Based on Hybridization Chain Reaction Signal Amplification for Detecting Biomarkers of Radiation-Resistant Nasopharyngeal Carcinoma and Imaging in Living Cells.

microRNA-205（miRNA-205）是鼻咽癌（NPC）放疗抵抗的预测性生物标志物，其定量检测对制定个体化治疗策略具有重要意义。本研究基于氧化石墨烯（GO）荧光猝灭平台和杂交链反应（HCR）信号放大策略，建立了一种高灵敏、高选择性检测miRNA-205的荧光生物传感器。该体系采用目标循环机制，单个miRNA-205分子可触发...