An isothermal electrochemical biosensor for the sensitive detection of microRNA based on a catalytic hairpin assembly and supersandwich amplification.
本文提出一种基于催化发夹组装(CHA)与超三明治(supersandwich)双重等温放大策略的电化学生物传感器,用于灵敏检测microRNA(miRNA)。由于miRNA-221在多种癌症中过表达,可作为相关疾病诊断的潜在生物标志物,作者以miRNA-221为模型靶标。靶标miRNA-221触发两条发夹底物通过toehold链置换...