RhoA is down-regulated at cell-cell contacts via p190RhoGAP-B in response to tensional homeostasis.

乳腺上皮细胞在柔顺的三维胶原凝胶中达到张力稳态时发生导管形态发生，该过程需要下调Rho活性。本研究在T47D细胞中比较p190RhoGAP-A与p190RhoGAP-B，发现p190RhoGAP-B而非p190RhoGAP-A介导柔顺三维胶原凝胶中RhoA活性下调和导管形态发生。RhoA与p190RhoGAP-B在细胞-细胞接触位点...