Sensitive biosensor for p53 DNA sequence based on the photothermal effect of gold nanoparticles and the signal amplification of locked nucleic acid functionalized DNA walkers using a thermometer as readout.

本文构建了一种用于检测p53 DNA序列的便捷光热生物传感器，其基于锁核酸（LNA）的高序列判别能力、DNA walkers的高效信号放大策略，以及聚集态与分散态金纳米颗粒（AuNPs）在近红外激光下光热效应的差异。当目标p53 DNA存在时，其与探针链中互补LNA序列高亲和杂交，激活DNA walkers，使walker链与sub...