Correlation between A3243G and G9053A mtDNA mutations and ATP levels in diabetes mellitus patients using qPCR and electrochemical aptasensors.
线粒体DNA(mtDNA)突变可损害氧化磷酸化和ATP生成,可能参与2型糖尿病(T2DM)发病。本研究旨在探讨T2DM患者血液和尿液中mtDNA突变与ATP水平的关系。共纳入60例患者,其中30例为T2DM合并线粒体病(MD)表型,30例为单纯T2DM。采用双标记探针实时荧光定量PCR(qPCR)检测A3243G和G9053A突变,...