Activation of the endoplasmic reticulum calcium sensor STIM1 and store-operated calcium entry by rotavirus requires NSP4 viroporin activity.

轮状病毒非结构蛋白4（NSP4）显著改变细胞钙稳态：增加内质网（ER）通透性、降低ER钙库并激活质膜（PM）钙内流通道，使胞质钙升高2至4倍。胞质钙升高是病毒复制必需，但钙内流机制不清。NSP4是ER定位病毒孔蛋白，其活性耗竭ER钙并导致钙内流。作者假设NSP4介导的ER钙耗竭通过激活ER钙传感器STIM1而激活store-oper...