Evolving to the optoelectronic mouse for phycotoxin analysis in shellfish.
Despite ethical and technical concerns, the in vivo method, or more commonly referred to mouse bioassay (MBA), is employed globally as a reference method for phycotoxi...
A novel firefly luciferase biosensor enhances the detection of apoptosis induced by ESAT-6 family proteins of Mycobacterium tuberculosis.
The activation of caspase-3 is a key surrogate marker for detecting apoptosis. To quantitate caspase-3 activity, we constructed a biosensor comprising a recombinant fi...
Enrichment of the β-catenin-TCF complex at the S and G2 phases ensures cell survival and cell cycle progression.
Wnt-β-catenin (β-catenin is also known as CTNNB1 in human) signaling through the β-catenin-TCF complex plays crucial roles in tissue homeostasis. Wnt-stimulated β-cate...
Single walled carbon nanotube-based junction biosensor for detection of Escherichia coli.
Foodborne pathogen detection using biomolecules and nanomaterials may lead to platforms for rapid and simple electronic biosensing. Integration of single walled carbon...
Label-free optical detection of biomolecular translocation through nanopore arrays.
In recent years, nanopores have emerged as exceptionally promising single-molecule sensors due to their ability to detect biomolecules at subfemtomole levels in a labe...
Graphene oxide-based SPR biosensor chip for immunoassay applications.
This work develops a highly sensitive immunoassay sensor for use in graphene oxide sheet (GOS)-based surface plasmon resonance (SPR) chips. This sensing film, which is...
Tunable optical filters with wide wavelength range based on porous multilayers.
A novel concept for micromechanical tunable optical filter (TOF) with porous-silicon-based photonic crystals which provide wavelength tuning of ca. ±20% around a worki...
A carbon nanotube/quantum dot based photoelectrochemical biosensing platform for the direct detection of microRNAs.
A versatile photoelectrochemical biosensing platform was developed based on DNA-CdS quantum dots (QDs) sensitized single-walled carbon nanotubes (SWCNTs)-COOH. Combini...
Resonant efficiency improvement design of piezoelectric biosensor for bacteria gravimetric sensing.
The piezoelectric biosensor have been widely used in ultra-small mass detection of biomolecular, based on PZT piezoelectric material can create a variety of compositio...
Enhancing sensitivity of surface plasmon resonance biosensors by functionalized gold nanoparticles: size matters.
We study how the size of spherical gold nanoparticles (AuNPs) influences their ability to enhance the response of optical biosensors based on surface plasmon resonance...
Development of isoform-specific sensors of polypeptide GalNAc-transferase activity.
Humans express up to 20 isoforms of GalNAc-transferase (herein T1-T20) that localize to the Golgi apparatus and initiate O-glycosylation. Regulation of this enzyme fam...
Highly sensitive graphene-Pt nanocomposites amperometric biosensor and its application in living cell H2O2 detection.
A sensitive hydrogen peroxide (H2O2) sensor was constructed based on graphene-Pt (RGO-Pt) nanocomposites and used to measure the release of H2O2 from living cells. The...
Detection of DNA using an "off-on" switch of a regenerating biosensor based on an electron transfer mechanism from glutathione-capped CdTe quantum dots to nile blue.
Although various strategies have been reported for double-stranded DNA (DNA) detection, development of a time-saving, specific, and regeneratable fluorescence sensing ...
Nanomaterials for biosensing applications: a review.
A biosensor device is defined by its biological, or bioinspired receptor unit with unique specificities toward corresponding analytes. These analytes are often of biol...
A novel fluorescent sensor protein for detecting changes in airway surface liquid glucose concentration.
Both lung disease and elevation of blood glucose are associated with increased glucose concentration (from 0.4 to ~4.0 mM) in the airway surface liquid (ASL). This per...
A novel electrochemical sensing strategy for rapid and ultrasensitive detection of Salmonella by rolling circle amplification and DNA-AuNPs probe.
A novel electrochemical sensing strategy was developed for ultrasensitive and rapid detection of Salmonella by combining the rolling circle amplification with DNA-AuNP...
Determination of cathepsin G in endometrial tissue using a surface plasmon resonance imaging biosensor with tailored phosphonic inhibitor.
OBJECTIVE: Cathepsin G is a serine peptidase whose physiological role is mainly associated with an early immune response, anti-microbial activity as well as platelet a...
Rapid in-vitro testing for chemotherapy sensitivity in leukaemia patients.
Bioluminescent bacterial biosensors can be used in a rapid in vitro assay to predict sensitivity to commonly used chemotherapy drugs in acute myeloid leukemia (AML). T...
Self-grown Ni(OH)(2) layer on bimodal nanoporous AuNi alloys for enhanced electrocatalytic activity and stability.
Au nanostructures as catalysts toward electrooxidation of small molecules generally suffer from ultralow surface adsorption capability and stability. Here, we report N...
Large-scale protein-protein interactions detection by integrating big biosensing data with computational model.
Protein-protein interactions are the basis of biological functions, and studying these interactions on a molecular level is of crucial importance for understanding the...