Real-Time Measurement of Cannabinoid Receptor-Mediated cAMP Signaling.
Cannabinoid receptors, like other GPCRs, signal via a spectrum of related signaling pathways. Recently, monitoring GPCR-mediated cAMP signaling has become significantl...
Fluorescent Protein-Based Turn-On Probe through a General Protection-Deprotection Design Strategy.
We demonstrated a general protection-deprotection strategy for the design of fluorescent protein biosensors through the construction of a turn-on Hg2+ sensor. A combin...
Plasmon-Based Colorimetric Nanosensors for Ultrasensitive Molecular Diagnostics.
Colorimetric detection of target analytes with high specificity and sensitivity is of fundamental importance to clinical and personalized point-of-care diagnostics. Be...
Improved Sensitivity of Acetaldehyde Biosensor by Detecting ADH Reverse Reaction-Mediated NADH Fluoro-Quenching for Wine Evaluation.
Acetaldehyde (AcH) is found in ambient air, foods, and the living body. This toxic substance is also contained in wine and known as an important ingredient affecting t...
Ultrasensitive Detection of Protein with Wide Linear Dynamic Range Based on Core-Shell SERS Nanotags and Photonic Crystal Beads.
Detection of proteins in a wide concentration range from fg mL-1 to sub mg mL-1 is a challenge in the high throughput analysis of precision medicine. Herein, we propos...
High performance electrochemical glucose sensor based on three-dimensional MoS
Two-dimensional (2D) nanosheets have been extensively explored as electrode materials for the development of high-performance electrochemical biosensors due to their u...
Highly efficient biosensors by using well-ordered ZnO/ZnS core/shell nanotube arrays.
We have studied the fabrication of highly efficient glucose sensors using well-ordered heterogeneous ZnO/ZnS core/shell nanotube arrays (CSNAs). The modified electrode...
The origin of high electrocatalytic activity of hydrogen peroxide reduction reaction by a g-C
Graphitic carbon nitride (g-C3N4) was synthesized from a low-cost precursor by means of a thermal process. The product was characterized by several spectroscopic techn...
Metamaterials and Metasurfaces for Sensor Applications.
Electromagnetic metamaterials (MMs) and metasurfaces (MSs) are artificial media and surfaces with subwavelength separations of meta-atoms designed for anomalous manipu...
Giant Magnetoresistive Biosensor Array for Detecting Magnetorelaxation.
In this paper, a time-domain magnetorelaxometry biosensing scheme is presented using giant magnetoresistive (GMR) sensors to measure the fast relaxation response of su...
Universal Ratiometric Photoelectrochemical Bioassay with Target-Nucleotide Transduction-Amplification and Electron-Transfer Tunneling Distance Regulation Strategies for Ultrasensitive Determination of microRNA in Cells.
A universal ratiometric photoelectrochemical (PEC) bioassay, which could be readily expanded for ultrasensitive determination of various targets in complex biological ...
Disposable Amperometric Polymerase Chain Reaction-Free Biosensor for Direct Detection of Adulteration with Horsemeat in Raw Lysates Targeting Mitochondrial DNA.
A novel electrochemical disposable nucleic acid biosensor for simple, rapid, and specific detection of adulterations with horsemeat is reported in this work. The biose...
Electroactive Biofilms for Sensing: Reflections and Perspectives.
Microbial electrochemistry has from the onset been recognized for its sensing potential due to the microbial ability to enhance signals through metabolic cascades, its...
Switchable Target-Responsive 3D DNA Hydrogels As a Signal Amplification Strategy Combining with SERS Technique for Ultrasensitive Detection of miRNA 155.
Usually, SERS technology requires labeling of the Raman reporter to obtain characteristic spectra for detection of biological samples. However, the number of labeled R...
A surface plasmon field-enhanced fluorescence reversible split aptamer biosensor.
Surface plasmon field-enhanced fluorescence is reported for the readout of a heterogeneous assay that utilizes low affinity split aptamer ligands. Weak affinity ligand...
Autoinducer Sensing Microarrays by Reporter Bacteria Encapsulated in Hybrid Supramolecular-Polysaccharide Hydrogels.
A generally applicable strategy to obtain mechanically robust hydrogels for the incorporation and containment of functional reporter bacteria for the microarray and mi...
Biosensor of alkaline phosphatase based on non-fluorescent FRET of Eu
Dephosphorylation of biomolecules under the catalysis of alkaline phosphatase (ALP) is a critical physiological process. Abnormal levels of ALP activity have been asso...
A Paper-Based Device for Performing Loop-Mediated Isothermal Amplification with Real-Time Simultaneous Detection of Multiple DNA Targets.
Paper-based diagnostic devices have many advantages as a one of the multiple diagnostic test platforms for point-of-care (POC) testing because they have simplicity, po...
Prototropically Allosteric Probe for Superbly Selective DNA Analysis.
Selective nucleotide recognition for biosensor evolution requires rational probe design toward the binding-pattern-susceptible readout but without serious poison in se...
Novel biomimetic enzyme for sensitive detection of superoxide anions.
Superoxide anion (O2•-), one of the most active reactive oxygen species (ROS) in micro-environment of the human body, is involved in some diseases if there is excess O...