Mechanochemical Sensing: A Biomimetic Sensing Strategy.
Existing biosensors employ two major components: analyte recognition and signal transduction. Although specificity is achieved through analyte recognition, sensitivity...
Label-free Protein Detection Based on the Heat-Transfer Method--A Case Study with the Peanut Allergen Ara h 1 and Aptamer-Based Synthetic Receptors.
Aptamers are an emerging class of molecules that, because of the development of the systematic evolution of ligands by exponential enrichment (SELEX) process, can reco...
A third-order mode high frequency biosensor with atomic resolution.
An atomic resolution ultra-high sensitivity surface acoustic wave (SAW) biosensor for DNA sequences and cells detection is proposed. Interdigitated transducers (IDTs) ...
An amplified electrochemical strategy using DNA-QDs dendrimer superstructure for the detection of thymine DNA glycosylase activity.
A triple-signal amplification strategy was proposed for highly sensitive and selective detection of thymine DNA glycosylase (TDG) by coupling a dendrimer-like DNA labe...
A simple and rapid label-free fluorimetric biosensor for protamine detection based on glutathione-capped CdTe quantum dots aggregation.
A novel fluorescent biosensor is developed, based on glutathione-capped CdTe quantum dots aggregation, for the determination of trace amount of an important drug, prot...
Submembrane ATP and Ca2+ kinetics in α-cells: unexpected signaling for glucagon secretion.
Cytoplasmic ATP and Ca(2+) are implicated in current models of glucose's control of glucagon and insulin secretion from pancreatic α- and β-cells, respectively, but li...
Electrochemical detection of Bisphenol A with high sensitivity and selectivity using recombinant protein-immobilized graphene electrodes.
A novel Bisphenol A (4,4'-isopropylidenediphenol, BPA) sensor was developed harnessing an electrochemical platform comprising a layer-by-layer assembled reduced graphe...
Fluorescent peptide-based sensors for the ratiometric detection of nanomolar concentration of heparin in aqueous solutions and in serum.
New fluorescent peptide-based sensors (1-3) for monitoring heparin in serum sample were synthesized using short peptides (1∼3mer) as a receptor. The peptide-based sens...
Surface plasmon resonance biosensor for highly sensitive detection of microRNA based on DNA super-sandwich assemblies and streptavidin signal amplification.
MicroRNAs (miRNAs) play an important regulatory role in cells and dysregulation of miRNA has been associated with a variety of diseases, making them a promising biomar...
Localization of the Dual Oxidase BLI-3 and Characterization of Its NADPH Oxidase Domain during Infection of Caenorhabditis elegans.
Dual oxidases (DUOX) are enzymes that contain an NADPH oxidase domain that produces hydrogen peroxide (H2O2) and a peroxidase domain that can utilize H2O2 to carry out...
Blood, sweat, and tears: developing clinically relevant protein biosensors for integrated body fluid analysis.
Biosensors are being developed to provide rapid, quantitative, diagnostic information to clinicians in order to help guide patient treatment, without the need for cent...
A facile and sensitive electrochemiluminescence biosensor for Hg2+ analysis based on a dual-function oligonucleotide probe.
In this study, a sensitive electrochemiluminescent (ECL) biosensor for the detection of Hg(2+) was easily prepared by self-assembling mercury-specific oligonucleotide ...
Novel electrochemical dual-aptamer-based sandwich biosensor using molybdenum disulfide/carbon aerogel composites and Au nanoparticles for signal amplification.
A new electrochemical aptamer biosensor for the platelet-derived growth factor BB (PDGF-BB) detection has been developed based on the signal amplification of MoS2/carb...
Mitoflash altered by metabolic stress in insulin-resistant skeletal muscle.
UNLABELLED: Central to bioenergetics and reactive oxygen species (ROS) signaling, the mitochondrion plays pivotal roles in the pathogenesis of metabolic diseases. Rece...
Amplified thrombin aptasensor based on alkaline phosphatase and hemin/G-quadruplex-catalyzed oxidation of 1-naphthol.
An alkaline phosphatase (ALP)-based biosensor can in situ generate an electroactive product by enzymatic hydrolysis of inactive substrates. To obtain a higher signal-t...
N-doped TiO2 based visible light activated label-free photoelectrochemical biosensor for detection of Hg(2+) through quenching of photogenerated electrons.
A novel photoelectrochemical (PEC) biosensor was fabricated based on N-doped TiO2 for the detection of Hg(2+) through the quenching of photogenerated electrons. The N-...
Rapid visual detection of eight meat species using optical thin-film biosensor chips.
Adulteration of meat products has become a very serious issue nowadays. To protect consumer rights, food labeling is required in many countries, and efficient and accu...
A novel electrochemical aptamer-antibody sandwich assay for lysozyme detection.
In this paper, we have reported a novel electrochemical aptamer-antibody based sandwich biosensor for the detection of lysozyme. In the sensing strategy, an anti-lysoz...
Predictor-Response Analysis of Fiber Optic Enzymatic Biosensors Constructed with Nonmodified E. coli BL21 (DE3) pGELAF+ Sensing 1,2-Dichloroethane.
Biosensor technology can lack methods to iteratively validate system outputs (i.e., signals) concomitantly with the development of mathematical models. We evaluated a ...
Catalytic Hairpin Assembly-Programmed Porphyrin-DNA Complex as Photoelectrochemical Initiator for DNA Biosensing.
A catalytic hairpin assembly (CHA)-programmed porphyrin-DNA complex was designed to trigger the chemiluminescence as photoelectrochemical initiator for DNA sensing. Fi...