Optical Bionanosensors for Sepsis Diagnostics.
Sepsis is a global health challenge, characterized by a dysregulated immune response, leading to organ dysfunction and death. Despite advances in medical care, sepsis ...
Simultaneous Detection of Multiple Analytes at Ambient Temperature Using Eukaryotic Artificial Cells with Modular and Robust Synthetic Riboswitches.
Cell-free systems, which can express an easily detectable output (protein) with a DNA or mRNA template, are promising as foundations of biosensors devoid of cellular c...
Ranking Single Fluorescent Protein-Based Calcium Biosensor Performance by Molecular Dynamics Simulations.
Genetically encoded fluorescent biosensors (GEFBs) have become indispensable tools for visualizing biological processes in vivo. A typical GEFB is composed of a sensor...
[Construction of a 17
17β-Estradiol (E2) is a natural steroidal estrogen essential for a variety of physiological functions in organisms. However, external E2, which is renowned for its pot...
A highly optimized and sensitive bowtie shape-based SPR biosensor for different analyte detection.
With advancements in photonic technologies, photonic crystal fibers (PCFs) have become crucial components in developing highly sensitive and efficient biosensors. This...
Hybrid Enzyme-Electrocatalyst Cascade Modified Gas-Diffusion Electrodes for Methanol Formation from Carbon Dioxide.
We propose a hybrid electrocatalytic-bioelectrocatalytic reaction cascade integrated on a gas diffusion electrode for CO2 reduction under selective formation of methan...
Biological Switches: Past and Future Milestones of Transcription Factor-Based Biosensors.
Since the description of the lac operon in 1961 by Jacob and Monod, transcriptional regulation in prokaryotes has been studied extensively and has led to the developme...
Enzyme fragment complementation driven by nucleic acid hybridization sans self-labeling protein.
A modified enzyme fragment complementation assay has been designed and validated as a turn-on biosensor for nucleic acid detection in dilute aqueous solution. The assa...
A wearable alcohol biosensor: Exploring the accuracy of transdermal drinking detection.
BACKGROUND: Trace amounts of consumed alcohol are detectable within sweat and insensible perspiration. However, the relationship between ingested and transdermally emi...
A sensitive ERK fluorescent probe reveals the significance of minimal EGF-induced transcription.
Extracellular signal-regulated kinase (ERK) regulates multiple cellular functions through distinct activation patterns. Genetically encoded fluorescent probes are inst...
Continuous Biosensing to Monitor Acute Systemic Inflammation, a Diagnostic Need for Therapeutic Guidance.
Continuous monitoring of acute inflammation can become a very important next step for guiding therapeutic interventions in severely ill patients. This Perspective disc...
A Small-Molecule Approach Enables RNA Aptamers to Function as Sensors for Reactive Inorganic Targets.
Fluorescent light-up aptamer (FLAP) systems are promising (bio)sensing platforms that are genetically encodable. However, FLAP-mediated detection of each distinct targ...
Enzyme-free detection of creatinine as a kidney dysfunction biomarker using TiO
TiO2 nanotube flow-through membranes (TNTsM) were fabricated via anodization of Ti foil and explored as a biosensing platform for creatinine detection. The electrodes ...
Inhibition of the upregulated phosphodiesterase 4D isoforms improves SERCA2a function in diabetic cardiomyopathy.
BACKGROUND AND PURPOSE: Sarcoplasmic reticulum Ca2+-ATPase (SERCA2a) is impaired in heart failure. Phosphodiesterases (PDEs) are implicated in the modulation of local ...
What hepatology clinicians and their patients with alcohol-related liver disease think of wearable alcohol biosensors to aid abstinence from alcohol: A qualitative study.
INTRODUCTION: We aimed to determine acceptability and feasibility of innovative wearable alcohol biosensor monitors (ABM) for patients with alcohol-related liver disea...
Near-infrared DNA biosensors based on polysulfonate coatings for the sensitive detection of microRNAs.
MicroRNAs (miRNAs) play crucial roles in the regulation of immune cell differentiation and the immune response during allergic rhinitis (AR). Studies have shown that m...
Tetrahedral DNA nanostructures, graphene and carbon nanodots-based electrochemiluminescent biosensor for BRCA1 gene mutation detection.
In this study, we present a novel electrochemiluminescent DNA biosensor designed for detecting breast cancer type 1 (BRCA1) gene mutations. The biosensor integrates gr...
High Quality-Factor All-Dielectric Metacavity for Label-Free Biosensing.
High sensitivity and high quality-factor are crucial for achieving outstanding sensing performance in photonic biosensors. However, strong optical field confinement an...
Biosensors for the detection of flaviviruses: A review.
Flaviviruses affect the lives of millions of people in endemic regions and also have the potential to impact non-endemic areas. Factors such as climate change, global ...
Mechanistic insights into the orthogonal functionality of an AHL-mediated quorum-sensing circuit in
YpsR, a pivotal regulatory protein in the quorum-sensing (QS) of Yersinia pseudotuberculosis(Y. pstb), is essential for molecular signaling, yet its molecular mechanis...